Exploring Potato Extract as a Multifunctional Drug Carrier

Abstract

This study, based on network pharmacology and molecular docking techniques, systematically explores the potential of potato (Solanum tuberosum) extract as a multifunctional drug carrier. By constructing three - dimensional pharmacophore models of glycoalkaloids (such as α - solanine) and polyphenolic compounds, and combining molecular docking, molecular dynamics simulation, and ADME/T prediction, the molecular mechanism of their synergistic effect with anti - cancer drugs is elucidated. The research results show that the active ingredients in potato extract can precisely target key anti - cancer targets such as EGFR, ACHE, TOP2A, and PIK3CA through hydrogen bonds, hydrophobic interactions, and π - π stacking, and reverse P - gp - mediated multidrug resistance. In addition, the synergistic effect of its cationic properties and the EPR effect enhances tumor targeting, providing theoretical support for the rational design of natural drug carriers.