Novel probiotic Lactiplantibacillus plantarum str. ZPZ as a possible candidate for “One Health” probiotic

Astghik Zavenovna Pepoyan; Vardan Victorovitch Tsaturyan; Vardges Agavardovitch Manukyan; Ivan Afanasyevich Egorov; Ilina Alexandrovna Ilina

Astghik Zavenovna Pepoyan Research Institute of Nutrition, Digestion and Biotechnology of the National Agrarian University of Armenia http://orcid.org/0000-0002-1935-5341
Vardan Victorovitch Tsaturyan Yerevan State Medical University https://orcid.org/0000-0003-4311-0747
Vardges Agavardovitch Manukyan FSC ARRTPI RAS http://orcid.org/0000-0003-4564-4427
Ivan Afanasyevich Egorov FSC ARRTPI RAS http://orcid.org/0000-0001-9122-9553
Ilina Alexandrovna Ilina BIOTROF Ltd http://orcid.org/0000-0003-2789-4844

Keywords: “One Health” concept, “One Health” probiotic, Lactiplantibacillus plantarum str. ZPZ, Klebsiella spp., agriculture

Abstract

One Health is a “collaborative, multisectoral, and transdisciplinary approach — working at the local, regional, national, and global levels to achieve optimal health outcomes recognizing the interconnection between people, animals, plants, and their shared environment”. Unlike "regular" probiotics (live microorganisms that, when administered in adequate amounts, confer a health benefit to the host), the “One Health” probiotics have to be valuable for the unity of people, animals, and the environment.
Given that Klebsiella spp. can be found in various environmental media: soil, water, plant/animal/human microflora, we aimed to evaluate the effects of Lactiplantibacillus plantarum str. ZPZ on the growth of K. pneumoniae spp. isolated from different sources: hospital’s departments, cow with mastitis and intestinal microbiota of fish. For this the probiotic’s cell-free cultures were used.
Current investigations show the effect of cell-free supernatants of Lpb. plantarum ZPZ on the growth of K. pneumoniae spp., isolated from both infected fish and sick with mastitis cow. This study supports our previous suggestion that Lpb. plantarum strains can be applied as One Health probiotics for use in the fields of agriculture and healthcare. According to this study, more specifically, Lpb. plantarum str. ZPZ is a prime example of a One Health probiotic.